MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7
نویسندگان
چکیده
منابع مشابه
Stimulation of cholesterol efflux by LXR agonists in cholesterol-loaded human macrophages is ABCA1-dependent but ABCG1-independent.
OBJECTIVE Maintenance of cholesterol homeostasis in human macrophages is essential to prevent foam cell formation. We evaluated the relative contribution of the ABCA1 and ABCG1 transporters to cholesterol efflux from human macrophages, and of the capacity of LXR agonists to reduce foam cell formation by stimulating export of cellular cholesterol. METHODS AND RESULTS ABCG1 mRNA levels were str...
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phage gene expression. Although the mechanisms by which oxidized LDL (oxLDL) regulates cellular gene expression are still poorly understood, recent work suggests that transcriptional pathways involving nuclear receptors mediate many biological effects of oxidized by providing the cell with oxidized fatty acid ligands of University of Debrecen the receptor (Nagy et al., 1998). The elucidation of...
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The LXR nuclear receptors are intracellular sensors of cholesterol excess and are activated by various oxysterols. LXRs have been shown to regulate multiple genes of lipid metabolism, including ABCA1 (formerly known as ABC1). ABCA1 is a lipid pump that effluxes cholesterol and phospholipid out of cells. ABCA1 deficiency causes extremely low high density lipoprotein (HDL) levels, demonstrating t...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2012
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2012.03.068